Monday, 16 December 2013

Beijing clinicians find changes in cause of infective endocarditis

Beijing researchers have clarified the underlying heart disease and microbiological pathogens associated with infective endocarditis in Chinese patients.
In a study of 115 adult patients admitted with infective endocarditis to Peking University First Hospital, Dr Li Xiangyan and co-researchers found that the most common underlying heart diseases were congenital heart disease (24%) followed by degenerative valvular disease (17.4%).
Aortic (44%) and mitral (43.5%) valves were most frequently affected.

The right-sided infective endocarditis cases were all found in patients with congenital heart disease. The age of patients was younger in right-sided cases than that in left-sided ones. There was no difference in the mortality among groups with different underlying heart disease. Forty-four (38%) patients were infected with viridans group streptococci. The isolation rate of staphylococci in right-sided infective endocarditis was higher than that in the left-sided infective endocarditis group. More than 85% of streptococci were susceptible to β-lactams.
The researchers concluded: “congenital heart disease and degenerative valvular disease have overtaken rheumatic heart disease as the major underlying heart diseases associated with infective endocarditis. Viridans group streptococci are the most common microbial cause of infective endocarditis.”
Full study: Internal Medicine Journal

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