Thursday, 20 December 2012

Breast cancer gene ESR1 found in Chinese women

A polymorphism near the oestrogen receptor gene (ESR1) (rs2046210) is associated with a risk of breast cancer in Chinese women, researchers from Wuhan have confirmed.
A case control study carried out at the Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, compared 461 cases of breast cancer and 537 controls from a Chinese Han population. It found that the rs2046210 A allele was significantly associated with breast cancer risk, with an increased risk of 32% This was confirmed in a meta-analysis integrating the current study and previous publications with a total of 53,379 cases and 55,493 controls. It found  a significant association between this polymorphism and breast cancer risk  in the overall population and especially among Asians. The increased risk was 14% higher overall and 27% higher among Asians.
Read more: PLOS One

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