Monday, 19 November 2012

Kunming researchers finds two stroke risk genes

Researchers in Kunming have identified two genes that are linked to an increased risk of ischaemic stroke in Chinese patients.
Writing in the journal Gene, they say that accumulating evidence indicates that the anti-inflammatory and anti-apoptotic functions of the Heat Shock Protein-70 (HSP7) family play an important role in cerebral ischemia. However, the association between HSP70 polymorphisms and ischaemic stroke are not well established.
They chose 101 cases of cerebral ischaemia and 100 healthy people from the Chinese Han population as study subjects, and analysed HSP70 polymorphisms.
There were no significant differences in + 1267A/G allele or genotype frequencies between patients with stroke and healthy controls. However, genotypes + 190CG, + 2437TT and T allele in HSP70-hom were risk factors of ischaemic stroke. Moreover, theit study showed that interactions between hypertension and + 190CG or + 2437TT genes may increase the risks of ischaemic stroke.
"The results from this study have suggested a clinical indicator for assessing the possibilities of cerebral stroke, and supply basis to clinicians to give precaution to people who are at risk of stroke," they conclude.

Read more: Gene

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